WebbThe intimate interaction of MHC class I expression by tumors and the T-cell immune pressure. One of the major problems facing any type of cancer treatment is the extensive heterogeneity of primary tumors, which arises as a result of genetic and epigenetic alterations at a clonal level [17••, 18].In a mouse model of 3-methyl-cholantrene-induced … Webbför 11 timmar sedan · In particular, the expression of MHC class I molecules on oligodendrocytes can lead to antigen-specific interaction with cytotoxic CD8 + T cells, resulting in oligodendrocyte death, at least in ...

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Webb30 maj 2003 · MHC class I downregulation is a widespread mechanism used by tumor cells to escape destruction by antitumor cytotoxic T lymphocytes. 9, 10 It has been proposed that the major factor that contributes to the appearance of MHC class I-negative tumor variants is T cell immunoselection. 11, 12 Currently, the origin of these MHC-negative … Histokompatibilitetskomplex (engelska: major histocompatibility complex, förkortas MHC) är det område på genomet som innehåller de gener som avgör utseendet hos serologiskt och lymfocytiskt definierade transplantationsantigener, immunsvarsassocierade antigener, samt för immunförsvarsgener, som kodar för de protein som reagerar på antigener. MHC kan även avse de protein som generna kodar för, och som har som funktion att binda antigen sccm msp detection method

Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer …

Webb71 et al., the alteration in the MHC expression is divided into two major groups: “Soft” alterations, 72 those capable of recovering or upregulating MHC antigens after cytokine exposure (e.g., reg-73 ulatory abnormalities); “Hard” alterations, those that cannot recover MHC expression (e.g., Webb1 maj 2014 · In this context, the broadened melanomareactive CD8 + T cell responses reported after anti-CTLA-4 therapy in melanoma [31 ,32,33 ] could be associated with the upregulation of MHC expression and ... WebbAntigens from apoptotic MHC-I deficient tumor cells were efficiently cross-presented by dendritic cells, resulting in heightened tumor infiltration by IFNa and TNFg-producing T cells. Tumors with a substantial population of MHC-I deficient cancer cells could be controlled by T cells when both pathways were targeted using genetic or … sccm ms