WebbWhile the strategy that Gunning takes in developing these molecules – targeting protein-protein interactions – has been quite successful and is turning out real drug candidates, it is tough work. Protein-protein interactions are non-contiguous contact points that can span surfaces of 1000 Å, and it is no small feat to produce a drug-like molecule capable … WebbSuch a catalog of connections could serve as a functional look-up table of the genome; we termed this concept the Connectivity Map (CMap). To date, CMap has generated a library containing over 1.5M gene expression profiles from ~5,000 small-molecule compounds, and ~3,000 genetic reagents, tested in multiple cell types. To produce data of that ...
New Diagnostic Approaches for Undiagnosed Rare Genetic Diseases
WebbProtein-protein interactions (PPIs) are the basis of many important cellular processes such as signal transduction, molecular transport and various metabolism pathways, while aberrant PPIs are the basis of multiple aggregation-related diseases, such as Alzheimer's disease, and may lead to cancer. Therefore, PPIs have been studied extensively in the … Webb1 mars 2024 · Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that … charged lineset
Parallelized identification of on- and off-target protein interactions ...
Webb23 feb. 2024 · Finnish researchers have identified a possible new targeted drug for treating acute myeloid leukemia. In the future, the discovery may help patients with certain rare subtypes of the disease. New promising targeted drug for a rare leukemia HiLIFE – Helsinki Institute of Life Science University of Helsinki Skip to main content Research WebbBackground:Over the last two decades, an increasing research effort in academia and industry has focused on the modulation (both inhibition and stabilization) of protein–protein interactions (PPIs) in order to develop novel therapeutic approaches and target-selective agents in drug discovery. WebbThe human knowledge network contains interactions between proteins, diseases, biological processes, side effects, and drugs. The network has 98 K nodes and 8 M edges, which are split into 42 distinct types of biologically relevant molecular interactions. View the Human Knowledge Network charged line rainwater system