Klf2 and macrophage
WebKLF2 is a member of the Krüppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and … WebOct 28, 2024 · KLF2 and MLKL overexpression was induced in macrophages using adenoviral constructs of KLF2 and MLKL (Ad-KLF2, Ad-MLKL, 1:100 MOI), empty vector as …
Klf2 and macrophage
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WebJul 20, 2015 · Macrophage inflammation is a key process of atherosclerosis. Macrophages ensure tissue cholesterol homeostasis by removing oxidized low-density lipoprotein … WebApr 3, 2012 · KLF2 Deficiency Increases Macrophage Adhesion to Endothelial Cells The increase in atherosclerosis observed in myeloid KLF2-deficient hypercholesterolemic mice may be due to elevated macrophage inflammation and/or propensity for lipid accumulation in response to atherogenic lipoprotein stimulation.
WebMar 21, 2024 · KLF2 is a novel inhibitor of HIF-1alpha expression and function. KLF2 regulates T cell trafficking by direct regulation of S1P (1) and CD62L and restrains … WebJan 6, 2024 · Thus, evolution has fashioned macrophages to orchestrate a coordinated inflammatory and hypoxic gene program to mount an effective immune response. Here, …
WebThe transcription factor Krüppel-like factor-2 (KLF2), and to a lesser extent KLF4, control the expression of many genes within the macrophage clearance program. These characteristics include high expression of receptors for apoptotic cells such as Tim4, but low expression of toll-like receptor (TLR)9 and reduced TLR responsiveness to nucleic ... WebRecent studies have linked Kruppel-like factors (KLFs) to the biology of macrophage activation and polarization ( 14. , 15. ). The initial link of this gene family to myeloid …
WebDec 28, 2024 · Given the role of Klf2 in cardiovascular development in mouse (Lee et al., 2006), we used the Transcription Activator-Like Effector Nuclease (TALEN) technology (Cermak et al., 2011) to mutate both klf2 paralogues in zebrafish (Figure 1A–B and Figure 1—figure supplement 1A–B), and identified a klf2a Δ10 allele (bns11) and a klf2b Δ8 allele …
WebApr 13, 2024 · KLF2 expression levels were found to be reduced in advanced cancer stages and grades, while positively correlated with the expression of estrogen receptor (ER), progesterone receptor (PR), and tumor size in breast cancer, according to the Tumor Immune Estimation Resource and Human Protein Atlas databases. Background: As a … pregnant woman shooting road rageWebAug 28, 2008 · Because KLF2 has been shown to play a particularly potent role in inhibiting endothelial cell and monocyte/macrophage activation, we focused our mechanistic studies on these 2 cell types. The key observation highlighted by our study relates to the role of KLF2 in monocyte/macrophage biology. pregnant woman shot after baby showerpregnant woman shot minneapolisWebSep 25, 2015 · Objective Recent evidence indicates that significant interactions exist between Kruppel-like factor 2 (KLF2) and microRNAs (miRNAs) in endothelial cells. Because KLF2 is known to exert anti-inflammatory effects and inhibit the pro-inflammatory activation of monocytes, we sought to identify how inflammation-associated miR-155 is regulated … pregnant woman sick of swimmingWebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. The activity of KLF2 is controlled by several … pregnant woman silhouette freeWebAug 6, 2014 · As several KLFs promote the anti-inflammatory program in macrophages, we propose that GR and KLFs functionally cooperate to curb inflammation. Electronic supplementary material The online version of this article (doi:10.1186/1471-2164-15-656) contains supplementary material, which is available to authorized users. pregnant woman silhouette pond5WebJun 16, 2024 · Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related tissue-supporting activities. ... This phenomenon is seen in the context of apoptotic cells clearance by peritoneal, pleural, and alveolar macrophages; the transcription factors KLF2 and KLF4 are central in the initiation of the apoptotic cell … scotch with chocolate notes