WebApr 15, 2011 · Hyperuricemia, hyperphosphatemia, and an elevated lactate dehydrogenase (LDH) level prior to the start of therapy for the malignancy also correlate with a risk of TLS developing.[1,2] ... TLS occurs when there is a rapid breakdown of nucleic acids and lysis of tumor cells during or in the days following chemotherapy initiation, … WebSep 1, 2003 · Background: Hyperuricemia and tumor lysis syndrome (TLS) are serious complications that can occur during chemotherapy for hematologic malignancies, even if standard management procedures, including administration of allopurinol, are undertaken. Rasburicase, a recombinant urate oxidase that converts uric acid (UA) into the soluble …

Drug-induced hyperuricaemia and gout - Oxford Academic

WebHyperuricemia can cause crystals of uric acid (or urate) to form. These crystals can settle in the joints and cause gout, a form of arthritis that can be very painful. They can also settle … WebGout is a metabolic disorder which is characterized by hyperuricemia and resultant deposition of monosodium urate in the tissues, particularly the joints and kidneys. The etiology of this hyperuricemia is the overproduction of uric acid in relation to the patient's ability to excrete it. If progressive deposition of urates is to be arrested or beamng jump map mods

Allopurinol Monograph for Professionals - Drugs.com

WebDivision of Clinical Chemotherapy, Sloan-Kettering Institute for Cancer Research, and the Departments of Medicine, Memorial and James Ewing Hospitals and Cornell University Medical College, New York ... used in 75 patients with leukemia or lymphoma treated with cytotoxic agents and has consistently prevented or reversed hyperuricemia. No uric ... Web2.4 Prevention of Hyperuricemia Take precautions against hyperuricemia (e.g., hydration, urine alkalinization, and prophylaxis with allopurinol) [see Warnings and Precautions (5.4)]. 2.5 Instructions for Handling, Preparation, and Administration Handling: Nelarabine injection is a cytotoxic agent. Caution should be used during handling and ... WebChemotherapy characteristics: Chemo-sensitive tumors, such as lymphomas, carry a higher risk for the development of tumor lysis syndrome. ... TLS should be suspected in patients with large tumor burden who develop acute kidney failure along with hyperuricemia (> 15 mg/dL) or hyperphosphatemia (> 8 mg/dL). (Most other acute kidney failure occurs ... di-log uk